2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-114611
    BDM44768 2011754-00-8 98%
    BDM44768 is an inhibitior of IDE. BDM44768 exacerbates ER stress-induced IRE1 activation and promotes lipid accumulation in hepatocytes. BDM44768 potentiates activation of the IRE1 pathway in the liver and exacerbates liver lipid accumulation in an acute mice model of ER stress.
    BDM44768
  • HY-114632
    Oxeglitazar 280585-34-4 98%
    Oxeglitazar is an orally active compound that can be used for the research of type II diabetes.
    Oxeglitazar
  • HY-114662
    Methyl 13-methylpentadecanoate 5487-50-3 98%
    Methyl 13-methylpentadecanoate is an ester product.
    Methyl 13-methylpentadecanoate
  • HY-114813
    KHG26693 1497249-95-2 98%
    KHG26693 is a thiazole derivative with anti-inflammatory and antioxidant properties. KHG26693 normalizes disturbed glucose metabolism by enhancing glucose utilization and decreasing liver glucose production via insulin release. KHG26693 is promising for research of diabetes.
    KHG26693
  • HY-114826
    Prostaglandin E2-1-glyceryl ester 37497-47-5 98%
    Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
    Prostaglandin E2-1-glyceryl ester
  • HY-114834
    AHL-157 158234-40-3 98%
    AHL-157 is a fibrate hypolipidemic agent. AHL-157 can decrease triglyceride, cholesterol, and blood sugar. AHL-157 can be used for the research of metabolic disease, such as hyperlipidemia and diabete .
    AHL-157
  • HY-114886
    IGP-5 351978-83-1 98%
    IGP-5 is a mitochondrial sn-Glycerol 3-phosphate Dehydrogenase (mGPDH) inhibitor with the IC50 of 0.7 μM aganist mGPDH H2O2 production . IGP-5 can be used for study of energy metabolism.
    IGP-5
  • HY-114947
    9-deoxy-9-methylene Prostaglandin E2 61263-32-9 98%
    9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.
    9-deoxy-9-methylene Prostaglandin E2
  • HY-115357
    BMS711939 1000998-62-8 98%
    BMS711939 is a selective agonist for peroxisome proliferator-activated receptor α (PPAR α), with EC50 of 4 nM and 4.5 μM, for human PPARα and human PPARγ. BMS711939 exhibits good pharmacokinetic characters in rats models. BMS711939 increases HDL cholesterol, reduces LDL cholesterol and triglycerides.
    BMS711939
  • HY-115421
    11(R)-HEPE 109430-11-7 98%
    11(R)-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid).
    11(R)-HEPE
  • HY-115434
    3,5-Diiodothyroacetic acid 1155-40-4 98%
    3,5-Diiodothyroacetic acid is a thyroid hormone analog. 3,5-Diiodothyroacetic acid lowers blood cholesterol concentrations. 3,5-Diiodothyroacetic acid can be used for hypothyroidism diseases research.
    3,5-Diiodothyroacetic acid
  • HY-115454
    GB111-NH2 956479-18-8 98%
    GB111-NH2 is a cysteine cathepsin inhibitor and can be used in cancer research.
    GB111-NH2
  • HY-115549
    AMPK activator 18 1364692-88-5 98%
    AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform. AMPK activator 18activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, with EC50 values of 17.2 and 82.1 nM. AMPK activator 18 stimulates β2-AMPK in cells, and glucose uptake by isolated skeletal muscle. AMPK activator 18 induces acetyl-coenzyme A carboxylase (ACC) and AMPK α-T172 phosphorylation. AMPK activator 18 can be used for the research of type 2 diabetes.
    AMPK activator 18
  • HY-115633
    Elagolix 2323071-30-1 98%
    Elagolix is an orally active, highly effective, selective and non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis.
    Elagolix
  • HY-115643
    AZ13581837 2896777-27-6 98%
    AZ13581837 is an orally active GPR120 agonist with an EC50 of 5.2 nM for human GPR120. AZ13581837 signals through Gαq, Gαs, and β-arrestin pathways, reduces cAMP production, stimulates GLP-1 secretion, induces glucose lowering, and increases insulin secretion. AZ13581837 can be used for the research of type 2 diabetes.
    AZ13581837
  • HY-115821
    Ascorutin 8067-12-7 98%
    Ascorutin (Rutascorbin), a combination of ascorbic acid and rutoside, is utilized in the treatment of diabetic retinopathy.
    Ascorutin
  • HY-115875
    LDHA-IN-5 2776148-90-2 98%
    LDHA-IN-5 is a novel, potent, dual GO/LDHA inhibitor for primary hyperoxaluria.
    LDHA-IN-5
  • HY-115899
    Malonyl CoA 524-14-1 98%
    Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1.
    Malonyl CoA
  • HY-115940
    Aldose reductase-IN-2 1687735-82-5 98%
    Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR). Aldose reductase-IN-2 has antioxidation capacity. Aldose reductase-IN-2 is a promising anti-diabetic complications agent.
    Aldose reductase-IN-2
  • HY-115978
    α-Glucosidase-IN-2 2699784-18-2 98%
    α-Glucosidase-IN-2 (compound 5d) is a potent α-Glucosidase inhibitor with an IC50 of 9.48 µM. α-Glucosidase-IN-2 is an antidiabetic agent.
    α-Glucosidase-IN-2
Cat. No. Product Name / Synonyms Application Reactivity